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Averica Discovery built a research services operation around SFC technology using Thar SFC instruments, a company now part of Waters Corporation.  Averica is pleased to be a Waters customer - our relationship with Waters gives us greater access to the breadth of their applications and technology expertise, and in turn, strengthens our services to our clients.

We're also pleased that Waters chose to feature Averica's President Jeff Kiplinger in a recent ad campaign, appearing in LCGC Magazine and on the inside cover of Chemical and Engineering News August 16 edition.

A poster presented at the 2010 HPLC Conference in Boston by Averica highlighted the use of hexane/alcohol admixures as liquid phase components of SFC eluents.  Hexane has some unique uses, including:

• Increasing the liquid concentration of the mobile phase without affecting separation
• Increasing k' (retention factor) of poorly retained compounds
• Changing the selectivity of the mobile phase, sometimes resulting in enhanced resolution

This poster offers some interesting new ideas for improving chromatography by using hexane/alcohol mixtures.

Contact info@avericadiscovery.com to request a poster reprint.

Whelk-O1 Pirkle-type selector

The Regis Technologies Whelk-O1 column is useful for the separation of underivatized enantiomers in a number of families including amides, epoxides, esters, ureas, carbamates, ethers, aziridines, phosphonates, aldehydes, ketones, carboxylic acids, alcohols and non-steroidal anti-inflammatory drugs (NSAIDs).  Its broad selectivity also makes it useful in achiral separations work.

This pi-electron acceptor/pi-electron donor phase exhibits an extraordinary degree of generality. In our applications at Averica, Whelk-O1 is screened first for selectivity in the early stages of method development.

Because Whelk-O1 is covalently bonded to the support, the phase is compatible with all commonly used mobile phases, including aqueous systems - a distinct advantage over polysaccharide chiral stationary phases.  We find the preparative columns among our most durable and efficient, and they often permit exceptionally high sample loads.

Whelk-O1 is available from Averica in both (R,R) and (S,S) selector configurations, allowing the user to reverse the order of  elution of isomers and obtain the desired compound at higher purity.