Physical Chemical Property

Averica SFC Sample

EPSA: A New Bioavailability / Permeability Assay

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EPSA: A New Bioavailability / Permeability Assay November 12, 2015 Predictive assays or calculations are established approaches to understanding a drug’s potential bioavailability.  A key physical property to understanding this is polar surface area, sometimes discussed as hydrogen bond availability.  The most common way of evaluating this is to calculate the structure’s Topological Polar Surface …

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Tailoring Custom Preformulation to a Challenging Compound

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Tailoring Custom Preformulation to a Challenging Compound April 21, 2014 One of our customers, a virtual pharma, worked with us on an advancing lead.  With two acidic functions it was and was highly water soluble except in strong acid, making profiling solubility across the gut tricky.  They needed a solubility assay from pH 1 to …

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Chiral Chromatography and your Distomer

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Chiral Chromatography and Your Distomer January 11, 2013 If you’re a discovery chemist using chiral chromatography to resolve a racemate for the first time, you don’t know which of the peaks you collect will be the active “eutomer” or the inactive “distomer”.  You probably have a way to find our with an easy bioassay.  You’ll experiment with …

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