Chiral Chromatography and Your Distomer

January 11, 2013

If you’re a discovery chemist using chiral chromatography to resolve a racemate for the first time, you don’t know which of the peaks you collect will be the active “eutomer” or the inactive “distomer”.  You probably have a way to find our with an easy bioassay.  You’ll experiment with the eutomer, maybe even find out more about its mechanism of action.  But what will you do with the distomer?

We’ve been thinking about this a lot recently, and there’s a lot that can be done.  Identifying useful salts.  Understanding physical properties.  Analytical method development.  Chemical process development.

Long story short, there’s too much value in that other vial to throw away.

If you have some ideas we haven’t thought of, contact us.  And if you have distomer samples sitting in the lab, think about what you might do with them.

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