Isolation of Pharmaceutical Impurities and Degradants Using SFC

Isolation of Pharmaceutical Impurities and Degradants Using SFC

April 4, 2013

Our paper, Isolation of Pharmaceutical Impurities and Degradants Using Supercritical Fluid Chromatography (SFC)” has been published in the March 2013 issue of Pharmaceutical Technology.

Isolation of trace impurities and degradants from mixtures containing primarily an API, or an API plus excipients, is often necessary for structure elucidation purposes. Using chromatographic methods for this purpose can be a slow and painstaking work.

Primary author Mickey Rego uses case studies to demonstrate that using supercritical fluid chromatography (SFC) offers distinct advantages in speed and in clean isolation of the desired peaks. These advantages are derived from three factors:

  1. Rapidity of method development
  2. Efficiency of the preparative fractionation
  3. Ease with which commonly used RP-HPLC chromatography data correlates with SFC.

Click here to access the complete paper.

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