Interest in chiral preparative chromatography using Supercritical Liquid Chromatography (SFC) continues to grow. The level of interest is illustrated by the launch of a number of new chiral columns within the last five years.

The rapidity with which SFC can process and purify compound is largely due to the enhanced fluidity of the mobile phase and its contribution to rapid chromatographic development. However, the characteristics of the column, especially the ability to absorb large loads of analyte while retaining good band shape, have an equally important role in determining separation efficiency.

In this presentation, we exhibit a systematic evaluation of some new stationary phases and consider the attributes of the column itself that contribute to efficient bulk preparative separations.