New Paper: SFC of Isomeric Polypeptides

New Paper: SFC of Isomeric Polypeptides

August 21, 2012

There’s a good paper with a new SFC application in the latest Journal of Chromatography A: “Packed column supercritical fluid chromatography of isomeric polypeptide pairs“. Several researchers at Pfizer teamed up with Larry Taylor at Virginia Tech to develop an easy and fairly general method for polypeptide analysis using 0.2% HFTA/methanol co-solvent with HA-Pyridine columns (Princeton Chromatography).

The results show (amazing? Is that too strong a word?) selectivity in resolving a series of very similar polypeptide isomers (about 1200 Da). Nice work!

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