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Averica Answers – What Percent Recovery Can I Expect?

In this video, Jeff Kiplinger discusses the factors that can influence recovery when using chromatography for purification. Well, we’d like to be able to give everyone 100% of the material they sent in back.  The problem is when we receive compounds we receive compounds of different qualities.  The purity of the material that you send in can have an impact on how much you actually recover. For example, if you sent a salt form and we sent back a free …

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Averica Answers – What Is Scalable Separation?

“What is Scalable Separation” briefly describes what  we mean when we talk about scalable separation. When we say scalable separations.  What we mean is that we develop each separation method so that it is scalable.  In other words, if you start with 100mg of compound that you need purified for some preliminary testing work – we can take that same separation method to 1g, 10g, 100g’s for advanced testing work.  So when I say scalable separation, what I mean is …

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LabTube Meets – Mickey Rego

LabTube houses a global of collection of scientific videos.  Their “LabTube Meets” segment interviews scientists about research, trends and technical innovations.  At Pittcon 2016 LabTube spoke with Mickey Rego about his presentation discussing ways prep chromatography can reduce risk in the early stages of drug development.Discover other great videos from Pittcon 2016, and scientists around the world, by visiting LabTube’s site.

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What Type of Chemist Are You?

Have you ever noticed there isn’t a personality chart for chemists?  There are plenty of chemistry roles in drug development, and we believe certain character traits enhance our ability to excel.  We’ve started this discussion using an alignment plot, and welcome all to join in our fun. Are you a chemist?  Where do you fall on the matrix?  Not a chemist – where would you be?  Want to know where we fall?  Our lab mostly falls into the Lawful/Evil spectrum. …

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InformEx: 5 min with Jeff Kiplinger 2016

Among the challenges the industry faces, which do you think are the most pressing?These open ended questions always make me think in big picture terms, and for a scientist this means I’m probably beyond my expertise! I think we need to consider re-inventing an R&D based culture.  The pharmaceutical industry has fallen into a trap similar to Hollywood studios – blockbuster products are so valuable that we can’t really invest in properties that might only earn several hundred million dollars …

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Averica Appoints Cynthia Berger, Ph.D., as VP Operations

Marlborough, MA, January 20, 2016 Averica Discovery, an analytical development contract research organization (CRO) with specialized expertise in small molecule analysis and purification, today announced the appointment of Cynthia Berger, Ph.D., to the newly-created position of Vice President of Operations. In her new role, Dr. Berger will directly report to CEO Jeff Kiplinger and is expected to contribute broadly to Averica’s growth and development. “We are excited to welcome Cindy, who will provide significant insight and guidance to our growth as an …

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How Do You Gauge the Success of a Marketing Investment in Cycling? (Part 3)

Finally, how can we analyze the impact of a cycling sponsorship on our brand and visibility?  The answer is “indirectly.” First, we see upticks in activity on social media when we directly engage our followers with specific news about the cycling team.  Tweets are retweeted, views of LinkedIn posts tick up.   Back Bay Cycling Club and Ride Studio Cafe helped us promote the launch of the team with a party last summer, and this got good social media buzz.  Because most …

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How Do You Gauge the Success of a Marketing Investment in Cycling? (Part 2)

Companies that sponsored cycling teams in the past thought of their investments as “rolling billboards.”  Particularly for the road racing disciplines, cyclists would wear their logo-covered jerseys and shorts in training and commuting as well as while racing, in theory increasing the likelihood that a customer – even one not interested  in biking – would recognize the logo when seeing it in another context.  Marketing people speak of “touches” – maximizing the tiny, maybe even subliminal, engagements of your brand …

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How Do You Gauge the Success of a Marketing Investment in Cycling?

Averica made a decision in 2014 to apply effort and investment to “inbound marketing,” the art of helping potential customers find us.  Inbound marketing recognizes that today consumers search for a provider instead of the vendor pitching to customers.  Think how door-to-door sales changed to cold calling, and changed again – now we research products and companies on the web and place orders directly online, with no human interaction in the sale at all. Inbound marketing requires that the potential …

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EPSA: A New Bioavailability / Permeability Assay

Predictive assays or calculations are established approaches to understanding a drug’s potential bioavailability.  A key physical property to understanding this is polar surface area, sometimes discussed as hydrogen bond availability.  The most common way of evaluating this is to calculate the structure’s Topological Polar Surface Area (TPSA) 1.  While valuable for rank ordering similar molecules, TPSA suffers by not accounting for conformational changes in a molecule in solution and does not account for potential Intramolecular Hydrogen Bonds (IMHB). EPSA, developed …

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