the processing of increasing quantities of a compound
May 24, 2016 Contracting tough projects with a CRO always requires active management, but some projects are complex enough that scope creep is a common problem. Impurity isolation falls into this category – the target impurity is an unknown, present at an uncertain level in a sample, and may not be stable. It’s a fun problem for …
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Averica Answers: What is Scalable Separation? Jeff Kiplinger April 7, 2016 Averica Answers is a series of short videos that each tackle a question we are often asked. “When we say scalable separations, what we mean is that we develop each separation method so that it is scalable. In other words, if you start with …
How to Calculate ROI on Discovery Scale-Up Choices January 19, 2015 “I have this degree in Chemistry, and now they want me to be an accountant?” Scientists have double the burden while working to move their compound forward, then having to stop and account for the costs. What are the economic rules for keeping a …
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Looking at Impurity Isolation Early Can Benefit Your Drug Development Process July 18, 2014 Jeffrey Kiplinger, President and Founder of Averica, answers questions about the role impurity isolation can play for start-ups. How can looking at impurity isolation at the beginning of drug development benefit a start-up? Startup companies focus on moving one or two related …
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What is Scalable Separation Using Supercritical Fluid Chromatography? Paul Lefebvre June 29, 2014 In this article Paul Lefebvre, Director of Laboratory Operations, responds to the question, “What is Scalable Separation using Supercritical Fluid Chromatography?” Scalable separation, also called preparative chromatography, is the production of any amount of compound, from 1 mg to 1 kg, using the same method. Supercritical …
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When Does Asymmetric Synthesis Make More Sense Than Chiral Resolution? June 20, 2014 In this article Jeffrey Kiplinger, President and Founder of Averica, responds to the question “When does asymmetric synthesis make more sense than chiral resolution?” Consider synthesis if it is fast and inexpensive, or if you know you have to get to a quantity …
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Benefits of Early Impurity Analysis to Pharmaceutical R&D August 27, 2013 We presented two/ posters at the CoSMoS 2013 (Conference on Small Molecule Spectroscopy) in San Diego this month. This poster titled Why Bother with the Little Peaks? Benefits of Early Impurity Analysis to Pharmaceutical R&D is a case study exploring the effectiveness of SFC in …
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