EPSA Assay 101: Background, Best Practices, & Success Stories
EPSA is a supercritical fluid chromatography (SFC) technique for peptides that enables improved permeability design and can be used as a permeability surrogate. This method is used to assess polarity by retention time using controlled SFC conditions in a standardized method.
In this webinar, Gilles Goetz, Ph.D., an original developer of EPSA, presents the background and preliminary implementation. We then hear from professionals in the industry about their own experiences using EPSA through a panel discussion and Q+A session.
To watch the webinar, simply fill out the form on the right.
About the Presenters
Gilles Goetz, Ph.D., Principal Scientist, Pfizer
Co-developer of the EPSA Assay, Gilles presents the background of EPSA and weighs in on how it is being implemented today.
Bill Farrell, Associate Research Fellow, Pfizer
Co-developer of the EPSA Assay, Bill discusses the assay’s new niche for large molecules and peptides alongside its original use for small molecules. Bill is the moderator of this event and weighs in during the Q+A session.
Romulo Romero, Analytical Scientist, AbbVie
Romulo is an analytical chemist with over 20 years in pharma discovery, currently focusing on SFC. He has an interest in automation and high throughput processes, as well as space exploration.
Huy Nguyen, Scientist, Genentech
Huy’s team focuses on running physchem, assays like LogD, EPSA, and solubility. In addition, his group utilizes microfluidics to develop novel physchem assays.
Johan Nicolaï, Sr. Research Scientist Investigative ADME, UCB
After obtaining his Ph.D., Johan joined UCB in 2016. Recently, he has been involved in the permeability of the Beyond Rule of 5 compounds.
Erin Jordan, Sr. Scientist I, AbbVie
Erin received her bachelor’s degree from University of Minnesota and Master’s in Chemistry from Northwestern University. While performing synthetic organic chemistry, she began her career at Abbott Labs in 2009 providing chiral purification support through process chemistry. Joining AbbVie in 2011, she currently co-leads the chiral SFC platforms supporting MedChem therapeutic teams.
Paul Lefebvre, General Manager, Averica Discovery
General Manager of Averica Discovery since 2018, Paul has worked in separations and purification for over 25 years. His experience with purification has been as both a vendor and a customer. Joining Averica in 2008, he has worked to grow the company into a full service chromatography CRO including purification by SFC and HPLC.