Experimental Polar Surface Area (EPSA)

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A fast and cost-effective method to determine the relative degree of polarity interaction in solution

Originally developed by Gilles Goetz et al at Pfizer, EPSA is a supercritical fluid chromatography (SFC) technique for peptides that enables improved permeability design and can be used as a permeability surrogate. This method is used to assess polarity by retention time using controlled SFC conditions in a standardized method.




The EPSA Assay

The EPSA assay is a valuable tool that expands access to information critical to interpretation of bioavailability and pharmacokinetics studies. The assay is straightforward to implement and reasonably fast on contemporary analytical scale SFC instrumentation. It is easily transferable, rugged and reliable.




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