Chiral Separation
SMall or Large scale chiral separation
We deliver finished compounds at scales for milligram to kilogram. Often smaller samples are processed in a few days, and the processes we develop are scalable as your program needs escalate.
Highly pure or isomerically pure test samples of drugs in development not only guarantee more reliable results, but are also absolutely required for certain types of testing – toxicity, for example. Waiting for a scalable chemistry process that can deliver material of high purity and chiral purity can delay a program. Our chromatography processes deliver qualified compounds fast.
The Averica Advantage
Fast and Easy To Scale-Up
Averica’s chromatography systems contain custom innovations, delivering the fastest turnaround and highest recovery without sacrificing any quality. Upon completion of a project clients receive highly pure compounds, an optimized method, and detailed reporting and analytics.
Averica’s depth of experience with HPLC method development and method qualification makes us uniquely suited to provide chromatography methods that result in projects delivered on time and on target.
Chromatography Solutions that fit your timeline and budget
Chiral Separation & Evaluation of Enantiomers
- Chromatography is your best solution for enantiomer supply at the early and intermediate stages of lead candidate profiling.
- Chiral separation is fast and easy to scale-up, so that you don’t have to worry about compound supply while moving a discovery program toward development.
- The high efficiency of preparative SFC delivers highly pure compound from milligrams to kilograms.
Chiral Method Development
We can develop chiral chromatography methods that are:
- Scalable for preparative chromatography use
- Normal phase or SFC for fast analysis and process monitoring
- Validation-ready for batch release and stability
- Reversed phase for bioanalysis
Preparative Chromatography
- Preparative chromatography also offers a reliable and cost-effective purification solution.
- Whether polishing a batch of compound to achieve a hard-to-meet purity standard, producing reference standard material, removing a problematic impurity, or isolating an unknown degradant; we apply the same highly efficient preparative SFC and HPLC technology to solve the problem
Fastest Turnaround & Highest Recovery
Highest Success Rate at Over 95%
Detailed Method Reprting & Analytics
US-based Scientific Team
Turnaround in DAYS, not Weeks or Months - Even at Larger Scale
DEA Schedule I-V Compounds
Success-oriented, Highly Responsive, & Experienced Team
Transferability
Instrument and Detective Systems
- SFC – Preparative & Analytical
- HPLC – Preparative & Analytical
- RP LC – Preparative & Analytical
- UPC^2
- UPLC
- GC
- ELSD
- MS
- CAD Detection
- PDA/UV
- NMR
- Accurate Mass MS